COMBASE

Los biocidas se utilizan en el tratamiento del crecimiento biológico perjudicial. Sin embargo, no sólo matan a los organismos patógenos, también matan a los no patógenos, lo que significa que pueden tener efectos secundarios indeseables, dañando la salud humana y / o el medio ambiente. Por ejemplo, en la fase de vida útil, cuando se liberan a los diferentes compartimentos medioambientales (suelo, aguas superficiales, aguas subterráneas y aire, dependiendo del uso del biocida), las sustancias activas experimentan una serie de reacciones de degradación que generan metabolitos, productos de transformación o reacción que podrían diferir significativamente de los compuestos progenitores en términos de su toxicidad asociada.
Considerando el impacto generado por las sustancias activas empleadas en productos biocidas así como el de los metabolitos, productos de degradación y transformación liberados al ambiente en las etapas de vida de aplicación y servicio, se requieren nuevas herramientas que permitan identificar y sustituir biocidas de relevancia ecotoxicológica desde una perspectiva de análisis de ciclo de vida.
El uso de métodos alternativos que no emplean animales ha sido previsto en el Reglamento (UE) 258/2012 (BPR – Biocidal Products Regulation) sobre productos biocidas. El uso generalizado de métodos no probatorios (NTM, Non Testing Methods) ayudaría a las PYME a identificar, entre otros, los llamados metabolitos de relevancia ecotoxicológica, facilitando al mismo tiempo el registro de sustancias biocidas en el marco de la BPR y la reducción de los ensayos con animales.
El objetivo principal del proyecto LIFE-COMBASE es promover el uso sostenible de las sustancias activas biocidas desde el punto de vista del ciclo de vida. Con este fin, se implementará un sistema de información en línea basado en la combinación de sistemas de apoyo a la toma de decisiones basados en evidencia (EBDSS) y modelos basados en toxicología computacional.

NOTICIAS/EVENTOS
21/07/2017
» Attendance to the BIOCIDES STAKEHOLDERS DAY

LIFE COMBASE will be present at the BIOCIDES STAKEHOLDERS DAY taking place on the 26th and 27th September at the ECHA in Helsinki. INKOA will attend this two day event: on the 26th three plenary sessions will take place: Biocides regulatory developments, Building a biocides application and Tips from authorities. On the 27th a training session on IT tools for biocides applications has been organized. Ideally, once the project has been implemented, the COMBASE Tool will be promoted by the different stakeholders involved in the authorisation of PPP and biocidal active substances. The attendance to this event constitutes a first step in the achievement of such goal. An additional output is that contacts will be established with different entities of industrial nature, future users of the COMBASE Tool. Finally, knowledge on other existing IT tools will be gained (IUCLID & R4BP3, mainly) therefore identifying possible complementarities that could eventually be established.

20/07/2017
» Preliminary program of the first international workshop of the LIFE COMBASE Project is now available

The first international workshop of the LIFE COMBASE Project will take place on the 19th October 2017 at the Istituto di Ricerche Farmacologiche Mario Negri (IRMFN) in Milan, Italy. During the workshop, which will be a one day event, the major outcomes of the project will be described. Furthermore, speakers representing regulatory agencies -such as the EFSA- and research institutions in the area of knowledge of QSAR and non-testing methods have been invited to participate. The present workshop constitutes a networking event for stakeholders in the biocides value chain including industries, regulatory bodies and research institutions. Registration is free of charge, if interested please write an email to info@life-combase.com. The programme is here here.

05/05/2017
» Survey available for the definition of requirements and specifications of the COMBASE Tool

The COMBASE consortium has now defined a survey for the identification of the requirements and specifications of the COMBASE Tool. Ideally, companies and regulators, main users of the developed tool, will provide their opinions in relation to the functionalities that the tool should have both considering the regulatory and practical perspective. Please, take a couple of minutes to fill in the survey for the definition of the requirements and specifications of the tool: you opinion matters and will help us improving. Access to the survey can be found on the next link.