Biocides are used in the treatment of damaging biological growth. However, not only do they kill pathogens, they also kill non-pathogens, meaning they may have undesirable side effects harming human health and/or the environment. For instance, in the service life phase, when released to the different environmental compartments (soil, surface waters, groundwater and air, depending on the actual use of the biocidal product), the active substances undergo a series of degradation reactions generating metabolites, transformation or reaction products that might significantly differ from the parent compounds in terms of their associated toxicity.
Considering the impact of active substances used in biocidal products and the metabolites, degradation and transformation products released to the environment during the application and service life phases, novel tools are necessary for the identification and substitution of biocides of ecotoxicological concern under an integrated life cycle perspective.
The use of non-animal alternative test methods has been foreseen in the Biocides Product Regulation, Regulation (EU) 258/2012 (BPR). The widespread use of non-testing methods (NTM) would help SMEs identifying, amongst other, the so called metabolites of ecotoxicological concern whereas facilitating the registering of biocidal active substances within the BPR and reducing animal testing.
The main target of the LIFE-COMBASE Project is to promote the sustainable use of biocidal active substances from a life cycle perspective. To this end, an on-line information system based on the combination of evidence based decision support systems (EBDSS) and proven computational toxicology modelling approaches will be implemented.


LIFE COMBASE will be present at the BIOCIDES STAKEHOLDERS DAY taking place on the 26th and 27th September at the ECHA in Helsinki. INKOA will attend this two day event: on the 26th three plenary sessions will take place: Biocides regulatory developments, Building a biocides application and Tips from authorities. On the 27th a training session on IT tools for biocides applications has been organized. Ideally, once the project has been implemented, the COMBASE Tool will be promoted by the different stakeholders involved in the authorisation of PPP and biocidal active substances. The attendance to this event constitutes a first step in the achievement of such goal. An additional output is that contacts will be established with different entities of industrial nature, future users of the COMBASE Tool. Finally, knowledge on other existing IT tools will be gained (IUCLID & R4BP3, mainly) therefore identifying possible complementarities that could eventually be established.

» Preliminary program of the first international workshop of the LIFE COMBASE Project is now available

The first international workshop of the LIFE COMBASE Project will take place on the 19th October 2017 at the Istituto di Ricerche Farmacologiche Mario Negri (IRMFN) in Milan, Italy. During the workshop, which will be a one day event, the major outcomes of the project will be described. Furthermore, speakers representing regulatory agencies -such as the EFSA- and research institutions in the area of knowledge of QSAR and non-testing methods have been invited to participate. The present workshop constitutes a networking event for stakeholders in the biocides value chain including industries, regulatory bodies and research institutions. Registration is free of charge, if interested please write an email to The programme is here here.

» Survey available for the definition of requirements and specifications of the COMBASE Tool

The COMBASE consortium has now defined a survey for the identification of the requirements and specifications of the COMBASE Tool. Ideally, companies and regulators, main users of the developed tool, will provide their opinions in relation to the functionalities that the tool should have both considering the regulatory and practical perspective. Please, take a couple of minutes to fill in the survey for the definition of the requirements and specifications of the tool: you opinion matters and will help us improving. Access to the survey can be found on the next link.